With the cobas® Mass Spec solution, which includes the cobas® i 601 analyzer and the Ionify® reagents line, you can step away from tedious and complex manual mass spectrometry workflows and experience the simplicity and convenience of a streamlined end-to-end solution.
From sample preparation to result interpretation, Roche will be consolidating four technologies onto a single platform—ISE, clinical chemistry, immunochemistry, and mass spectrometry—maximizing efficiency and delivering enhanced medical value. Our solution is designed to enable smart testing through seamless physical and digital connectivity with other analytical units.
A broad assay menu of Ionify reagents is in development, complementing the clinical chemistry and immunoassay portfolio available on cobas pro integrated solutions. The assays include ready-for-use test kits with consistent performance and traceability to reference methods.
Enhance your lab’s capabilities by complementing existing methodologies and expanding services to new patient populations and disease areas with mass spectrometry.1-3 The cobas i 601 analyzer allows you to streamline current workflows that require dedicated and specialized staff.
Contact us to discover how mass spectrometry can seamlessly integrate into your routine laboratory, enabling broader access to this transformative technology.
A total automated solution from sample preparation to result interpretation saving hands-on time for your operators.
Convenient and continuous sample loading
Random access processing: No waiting, sorting, or re-engineering required
Automated sample preparation from biological sample to purified analyte
Automated analyte separation: Automatic onboard mixing with 8 system reagents onboard and 8 channels of LC columns with efficient automated cleaning
Automated detection and quantification of analytes: Triple quadrupole mass spectrometer with electrospray ionization (ESI) technology
Automated result validation and reporting: Data processing, analyte quantification, result validation, reporting, and flagging
Fully integrated* into routine clinical chemistry and immunochemistry testing, as well as laboratory automation, this solution enhances productivity in your lab.
Designed to meet your laboratory’s needs, the cobas i 601 analyzer is part of cobas pro integrated solutions and will work in combination* with cobas® ISE neo, cobas® c 503, and cobas® e 801 analytical units. It is also designed to integrate into pre- and post-analytics and IT solutions.
*At launch, cobas i 601 analyzer is available in a single configuration <cobas pro SSU | i 601>. All other configurations will be available at a later date and are not currently licensed for sale in Canada.
The cobas i 601 analyzer has a high throughput with up to 100 injections per hour to fit the needs of your routine laboratory. This is made possible through its design features focused on automation, helping you deliver faster and more predictable turnaround times.
cobas i 601 analyzer offers a broad in vitro diagnostics menu of Ionify® reagents with more than 60 assays under development in the area of steroids, vitamin D, therapeutic drug monitoring, as well as drugs of abuse testing. They will be consolidated into multi-analyte, RFID-labelled reagent cassettes, which can be easily loaded and automatically registered into the system with 48 reagent channels.
The cobas i 601 analyzer is designed to optimize operational efficiency and ensure seamless performance through a range of advanced features, including:
Automating the majority of maintenance tasks
Minimum daily operator intervention
Easy to perform, even for non-mass spectrometry experts
Step-by-step guidance for the operators
Continuous system monitoring to speed up troubleshooting and reduce time to repair
The cobas i 601 analyzer, Ionify reagents, methods, and workflows comply with the In Vitro Diagnostic Medical Device Regulation (IVDR). All assay designs, including pre-analytic and analytic protocols, data acquisition, and calibration and quality controls, provide an unbroken traceability chain to reference measurement procedures. This solution ensures quality performance, enabling consistent results across laboratories and supporting better patient care.
With standardized, ready-for-use reagent packs, cartridges, and system reagents, the cobas i 601 analyzer minimizes hands-on time. This design reduces operator contact with hazardous materials, enhancing both convenience and safety.
The cobas® i 601 analyzer is an integrated fully automated, random-access, software controlled clinical analyzer for paramagnetic particle-based sample preparation, liquid chromatography and mass spectrometry analysis for quantitative in-vitro determinations.
The cobas® i 601 analyzer is intended to identify naturally occurring and synthetic compounds (e.g., steroids, vitamins, and others) in human specimens by ionizing the compound under investigation and the resulting ions by means of an electrical and magnetic field according to their mass-to-charge ratio.
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Easy-to-use, fully automated, integrated, and standardized end-to-end solution bringing mass spectrometry to routine testing environments. It is part of cobas® pro integrated solutions, featuring a consistent design and user-friendly interface—reducing the need for extensive staff training.
Sample loading and unloading in a five-position rack with a capacity of up to 300 samples, allowing for continuous loading. STAT port for emergency samples.
Designed to offer a true random access buffer for samples. Holds up to 25 five-position racks (125 samples). Positions can also be dedicated for STAT rack handling.
Purification of the analytes occurs through paramagnetic particle-based sample preparation procedures, allowing automated testing in random access mode. The reagent manager consists of 48 positions in a cooled reagent rotor, enables the loading of reagent cassettes on the fly, and features an RFID reader
The system enables the separation of analytes via columns in ready-for-use cartridges with RFID labels. It incorporates both HPLC and rapid liquid chromatography (LC) technologies to cover different selectivities. Automatic onboard mixing of mobile phases and eight parallel channels of LC columns supports high throughput—up to 100 injections per hour—and allows for random access testing. Additionally, most system reagents can be loaded on the fly to maintain uninterrupted…
Detection and quantification of the analytes occur in a triple quadrupole tandem mass spectrometer with electrospray ionization (ESI) technology.
References
Grebe SK, Singh RJ. LC-MS/MS in the Clinical Laboratory - Where to From Here?. Clin Biochem Rev. 2011;32(1):5-31.
Hristova J & Svinarov D. Enhancing precision medicine through clinical mass spectrometry platform. Biotechnology & Biotechnological Equipment. 2022;36(1):107-117.
Ketha SS, Singh RJ, Ketha H. Role of Mass Spectrometry in Clinical Endocrinology. Endocrinol Metab Clin North Am. 2017;46(3):593-613.
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