CD8 is a transmembrane glycoprotein expressed by cytotoxic T-cells and at low levels in NK-cells and a subpopulation of bone marrow cells1-3. A cytotoxic T-cell marker, CD8 positive T-cells are mainly involved in cytotoxic immunoreactions4. CD8 is absent on immature T-cells and expressed in later stages of T-cell development as the cell matures into a cytotoxic T-cell5-6. CD8 (SP239) Rabbit Monoclonal Primary Antibody is intended for laboratory use in the qualitative immunohistochemical detection of CD8 by light microscopy in sections of formalin-fixed, paraffin-embedded tissue stained on a BenchMark IHC/ISH instrument.
Benefits of CD8 (SP239) antibody:
• In vitro diagnostic; Ready to use
• Recombinant technology offering consistent and reproducible results
• In a comparison antibody test by NordiQC, CD8 (SP239) antibody scored “optimal” and equivalent to the NordiQC reference antibody7
• A cornerstone product in the Roche hematopathology tissue menu, a comprehensive offering of over 70 robust IHC and ISH assays supported by innovative detection, automation and workflow solutions
References
1 Dabbs DJ. Diagnostic Immunohistochemistry Theranostic and Genomic Applications, 5th edition. Vol 5. Amsterdam, Netherlands: Elsevier; 2019.
2 Higgins RA, Blankenship JE, Kinney MC. Application of immunohistochemistry in the diagnosis of non-Hodgkin and Hodgkin lymphoma. Arch Pathol Lab Med. 2008; 132(3):441-461.
3 Naeim F. Principles of Immunophenotyping. In Naeim F, Rao PN, Grody WW, eds. Hematopathology: Morphology, Immunophenotype, Cytogenetics, and Molecular Approaches. Cambridge, MA: Academic Press; 2009.
4 https://www.nordiqc.org/epitope.php?id=22. Accessed 19 April 2023.
5 Rich R, Fleisher T, Shearer W, Frew A, Weyand C. Clinical Immunology Principles and Practice, 5th edition. Vol 5. Amsterdam, Netherlands: Elsevier, 2018.
6 Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edition. Vol 4. Lyon, France: International Agency for Research on Cancer; 2008.
7 Data on file